EVALUATING THE PREDICTED RELIABILITY OF MECHATRONIC SYSTEMS: STATE OF THE ART

Reliability analysis of mechatronic systems is one of the most young field and dynamic branches of research. It is addressed whenever we want reliable, available, and safe systems. The studies of reliability must be conducted earlier during the design phase, in order to reduce costs and the number of prototypes required in the validation of the system. The process of reliability is then deployed throughout the full cycle of development; this process is broken down into three major phases: the predictive reliability, the experimental reliability and operational reliability. The main objective of this article is a kind of portrayal of the various studies enabling a noteworthy mastery of the predictive reliability. The weak points are highlighted, in addition presenting an overview of all approaches existing in quantitative and qualitative modeling and evaluating the reliability prediction is so important for the futures reliability studies, and for academic researches to innovate other new methods and tools. the Mechatronic system is a hybrid system; it is dynamic, reconfigurable, and interactive. The modeling carried out of reliability prediction must take into account these criteria. Several methodologies have been developed in this track of research. In this article, we will try to handle them from a critical angle

Evaluating the predicted reliability of mechatronic systems: state of the art

Reliability analysis of mechatronic systems is a recent field and a dynamic branch of research. It is addressed whenever there is a need for reliable, available, and safe systems. The studies of reliability must be conducted earlier during the design phase, in order to reduce costs and the number of prototypes required in the validation of the system. The process of reliability is then deployed throughout the full cycle of development. This process is broken down into three major phases: the predictive reliability, the experimental reliability and operational reliability. The main objective of this article is a kind of portrayal of the various studies enabling a noteworthy mastery of the predictive reliability. The weak points are highlighted. Presenting an overview of all the quantitative and qualitative approaches concerned with modelling and evaluating the prediction of reliability is so important for future reliability studies and for academic research to come up with new methods and tools. The mechatronic system is a hybrid system, it is dynamic, reconfigurable, and interactive. The modeling carried out of reliability prediction must take into account these criteria. Several methodologies have been developed in this track of research. In this regard, the aforementioned methodologies will be analytically sketched in this paper.Comment: 13 page, Mechanical Engineering: An International Journal (MEIJ), Vol. 3, No. 2, May 201

A Combined Synthetic-Fibrin Scaffold Supports Growth and Cardiomyogenic Commitment of Human Placental Derived Stem Cells

Aims: A potential therapy for myocardial infarction is to deliver isolated stem cells to the infarcted site. A key issue with this therapy is to have at one\u27s disposal a suitable cell delivery system which, besides being able to support cell proliferation and differentiation, may also provide handling and elastic properties which do not affect cardiac contractile function. In this study an elastic scaffold, obtained combining a poly(ether)urethane-polydimethylsiloxane (PEtU-PDMS) semi-interpenetrating polymeric network (s-IPN) with fibrin, was used as a substrate for in vitro studies of human amniotic mesenchymal stromal cells (hAMSC) growth and differentiation. Methodology/Principal Findings: After hAMSC seeding on the fibrin side of the scaffold, cell metabolic activity and proliferation were evaluated by WST-1 and bromodeoxyuridine assays. Morphological changes and mRNAs expression for cardiac differentiation markers in the hAMSCs were examined using immunofluorescence and RT-PCR analysis. The beginning of cardiomyogenic commitment of hAMSCs grown on the scaffold was induced, for the first time in this cell population, by a nitric oxide (NO) treatment. Following NO treatment hAMSCs show morphological changes, an increase of the messenger cardiac differentiation markers [troponin I (TnI) and NK2 transcription factor related locus 5 (Nkx2.5)] and a modulation of the endothelial markers [vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR)]. Conclusions/Significance: The results of this study suggest that the s-IPN PEtU-PDMS/fibrin combined scaffold allows a better proliferation and metabolic activity of hAMSCs cultured up to 14 days, compared to the ones grown on plastic dishes. In addition, the combined scaffold sustains the beginning of hAMSCs differentiation process towards a cardiomyogenic lineage